Every single hour of television watched after the age of 25 reduces the viewer’s life expectancy by 22 minutes

By comparison, smoking a single cigarette reduces life expectancy by about 11 minutes.

An adult who spends an average of six hours a day watching TV over the course of a lifetime can expect to live 4.8 years fewer than a person who does not watch TV.

References:

Get Up. Get Out. Don't Sit. - NYTimes, 2012 http://nyti.ms/10oXBQd

Comments from Twitter and Google Plus:

Humera Naqvi, MD @nayab78: hmmm that means we ppl should be dying early taking the amount of tv watched but life expectancy has increased.

K Dillon, RDMS,CPC-A @comalliwrites: Confounders & confirmation bias not accounted for...

@ShadolooDoll: Misleading. It isn't TV itself, but the lack of activity. A person who is dedicated to exercise can still watch TV, right?

Timothy Cook: Great, since I stopped watching TV.  I can start smoking again!  ;-)

Davíð Þórisson: Phew - no mention of watching Youtube! :-)

Jimena Yosara Aguilar Jimenez: I'll never watch tv again

Dimiter Stanev: Does that mean that disabled people suffer from this too?

Image source: Wikipedia, Creative Commons Attribution ShareAlike 2.5 License.

Being obese at age 40 reduces life expectancy by 7 years for women and 6 years for men

In Scotland 68.5% of men, 61.8% of women, 36.1% of boys, and 26.9% of girls are classified as overweight or obese.

Being obese at age 40 reduces life expectancy by 7.1 years for women and 5.8 years for men.

The article summarises the most recent recommendations from the Scottish Intercollegiate Guidelines Network (SIGN) on the management of obesity.

References:
Management of obesity: summary of SIGN guideline. Logue et al. 340: c154. BMJ, 2010.

Comments from Google Buzz:

Luke Rosenberger - thanks! looks like original source of the life expectancy data (according to footnote) is actually a 2003 article from annals of internal medicine - http://www.ncbi.nlm.nih.gov/pubmed/12513041

Ves Dimov, M.D. - Looks correct. That's why I always say that we need a medical librarian on board... :)

For Google Buzz and Twitter, I typically link to the source where the text appeared when I first saw it. It's very nice to trace it back to the original source however. Thank you so much.

Luke Rosenberger - makes sense to me. you know us librarians, always reading the footnotes first ;-)

Image source: Wikipedia, public domain.

Increasing Diet Polyunsaturated Fat in Place of Saturated Fat Reduces Risk of Coronary Heart Disease

Reduced saturated fat (SFA) consumption is recommended to decrease coronary heart disease (CHD), but there is an absence of strong supporting evidence from randomized controlled trials (RCTs) of clinical CHD events and few guidelines focus on any specific replacement nutrient. Additionally, some public health groups recommend lowering or limiting polyunsaturated fat (PUFA) consumption, a major potential replacement for SFA.

The overall pooled risk reduction was 19% (RR = 0.81), corresponding to 10% reduced CHD risk (RR = 0.90) for each 5% energy of increased PUFA.

These findings provide evidence that consuming PUFA in place of SFA reduces CHD events in RCTs. This suggests that rather than trying to lower PUFA consumption, a shift toward greater population PUFA consumption in place of SFA would significantly reduce rates of CHD.

References:

Mozaffarian D, Micha R, Wallace S (2010). Effects on Coronary Heart Disease of Increasing Polyunsaturated Fat in Place of Saturated Fat: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS Med 7(3): e1000252. doi:10.1371/journal.pmed.1000252
The long history of dieting fads: "soap should be eaten for its diuretic properties", wrote a prominent surgeon in 1810. Lancet, 2012.
How We Eat: Analyzing Half a Million Meals - 5 INFOGRAPHICS

Top diets of 2012 - from Cleveland Clinic health blog http://buff.ly/X2I4BJ

Image source: Varieties of meat, Wikipedia, public domain.

Aspirin 75 mg daily reduces incidence and mortality due to colorectal cancer

High-dose aspirin (≥500 mg daily) reduces long-term incidence of colorectal cancer, but adverse effects (bleeding) might limit its potential for long-term prevention. The long-term effectiveness of lower doses (75-300 mg daily) is unknown. This study in The Lancet assessed the effects of aspirin on incidence and mortality due to colorectal cancer over 20 years.

In the four trials of aspirin versus control (mean duration of treatment 6 years), 2·8% of 14,000 patients had colorectal cancer during a follow-up of 18 years.

Aspirin reduced the 20-year risk of colon cancer (incidence hazard ratio [HR] 0·76, but not rectal cancer (0·90).

Where subsite data were available, aspirin reduced risk of cancer of the proximal colon (0·45), but not the distal colon (1·10). Benefit increased with duration of treatment - aspirin taken for 5 years or longer reduced risk of proximal colon cancer by 70% and also reduced risk of rectal cancer (0·58).

There was no increase in benefit at doses of aspirin greater than 75 mg daily. However, risk of fatal colorectal cancer was higher on 30 mg versus 283 mg daily.

Aspirin taken for several years at doses of at least 75 mg daily reduced long-term incidence and mortality due to colorectal cancer. Benefit was greatest for cancers of the proximal colon, which are not otherwise prevented effectively by screening with sigmoidoscopy or colonoscopy.

References:
Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. The Lancet, Volume 376, Issue 9754, Pages 1741 - 1750, 20 November 2010.

Image source: Colon (anatomy), Wikipedia, public domain.

Acyclovir reduces risk of HIV-1 disease progression, if positive for HIV-1 and HSV-2

Most people infected with HIV-1 are dually infected with herpes simplex virus type 2. Daily suppression of this herpes virus reduces plasma HIV-1 concentrations, but whether it delays HIV-1 disease progression is unknown.

In this study, the median CD4 cell count at enrollment was 462 cells per μL and median HIV-1 plasma RNA was 4 log10 copies per μL. Aciclovir reduced risk of HIV-1 disease progression by 16%.

The role of suppression of herpes simplex virus type 2 in reduction of HIV-1 disease progression before initiation of antiretroviral therapy warrants consideration.

References:

Daily aciclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trial. The Lancet, Volume 375, Issue 9717, Pages 824 - 833, 6 March 2010.

Image source: Diagram of HIV. Image source: Wikipedia.