Showing posts with label drug. Show all posts
Showing posts with label drug. Show all posts

"Wonder drug" dogs are the only animals that look at right side of human face where emotions are expressed

Dogs are the most diverse mammal species on the planet (http://buff.ly/1pxxt0k). People who have dogs as pets are much less likely to have a heart attack. If they do have a heart attack, they are 2-3 times more likely to survive it.

Mitochondrial genetics studies have shown conclusively that dogs have descended from wolves. Dogs' genes are 99.8% the same as the wolf genes, yet dogs behave in a fundamentally different way.

Over more than 100,000 years dogs have evolved to recognize human emotions. It has been a collaborative process all along. Humans are able to recognize 6 types of dog barks expressing emotions and "intentions" such as fear, excitement, aggression and so on. Dogs are the only animals that specifically look at the right side of the human face where emotions are expressed (see the NOVA video and website below).

Dogs follow directions while chimpanzees, the apes evolutionary closest to humans, do not. The smartest dog can learn 300 different words which is the vocabulary size of a 2-year-old child.

The "400 mnemonic":

400 million dogs worldwide
400 breeds of dogs have been developed by humans

According to a Cleveland Clinic psychologist, "dogs could be called wonder drugs":

"Dogs can provide people with many things. Protection, friendship, and unconditional love top the list, but they may also provide health benefits, too." How smart are dogs, and what makes them such ideal companions? Dogs Decoded: Nova. Netflix. Comments from Twitter: Heidi Allen @dreamingspires: I want one! References: Dogs Decoded transcript and more. NOVA. Image source: Yellow Labrador Retriever, Wikipedia, GNU Free Documentation License.
87% of people older than 50 took one or more drug, according to
Australian survey

87% of people older than 50 took one or more drug, according to Australian survey

A postal survey included a random sample of 4,500 Australians aged ≥ 50 years between in 2009-2010 and the response rate was 37%.

Medications use was very common, 87% of participants took one or more drug (called medicines in Australia) and 43% took five or more in the previous 24 hours.

Complementary medicines were used by 46% of participants.

The most commonly used medications were:

- antihypertensive agents, 43% of participants
- natural marine and animal products including fish oil and glucosamine, 32%
- lipid-lowering agents, 30%

Doctors recommended 79% of all medications and 93% of conventional medications.

Much medicines use was to prevent future disease by influencing risk factors.

In a 2011 study, 4 medication classes were linked to 67% of drug-related hospitalizations:

- warfarin, 33%
- insulins, 14%
- oral antiplatelet agents, 13%
- oral hypoglycemic agents, 11%

High-risk medications were implicated in only 1.2% of hospitalizations.

50% of these hospitalizations were among adults 80 years of age or older. 65% of hospitalizations were due to unintentional overdoses.

Classification of adverse reactions to drugs: "SOAP III" mnemonic (click to enlarge the image):



Adverse drug reactions (ADRs) affect 10–20% of hospitalized patients and 25% of outpatients.

Rule of 10s in ADR:

10% of patients develop ADR
10% of these are due to allergy
10% of these lead to anaphylaxis
10% of these lead to death

References:

A national census of medicines use: a 24-hour snapshot of Australians aged 50 years and older. Tessa K Morgan, Margaret Williamson, Marie Pirotta, Kay Stewart, Stephen P Myers and Joanne Barnes. MJA 2012; 196 (1): 50-53, doi: 10.5694/mja11.10698

4 medication classes linked to 67% of drug-related hospitalizations

Image source: Wikipedia, public domain.
Old drug, new warnings: Acetaminophen (paracetamol, Tylenol)

Old drug, new warnings: Acetaminophen (paracetamol, Tylenol)

Acetaminophen is the leading cause of acute liver failure in the United States. Nearly half of acetaminophen-associated cases are due to unintentional overdose.

Especially vulnerable patients are:

- taking enzyme-inducing drugs
- chronic users of alcohol
- malnourished

Although no consensus has been reached on what is a safe dose in patients with liver disease, 4 g/day is too much: a total daily dose of no more than 2 g is recommended to decrease the risk of toxicity in these patients.

The US Food and Drug Administration (FDA) is considering banning acetaminophen-narcotic combination products.

References:
Acetaminophen: Old drug, new warnings. Cleveland Clinic Journal of Medicine January 2010 vol. 77 1 19-27.
Image source: Amazon, used for illustrative purposes only - NOT a suggestion to purchase any medications.