Italian Hand Gestures - a Short History in a NYTimes Video

Can Italians talk without using their hands? Gestures offer a window into Roman culture. Read the story here: http://nyti.ms/1avwKYQ



Some gestures are simple but others are far more complex. They add an inflection — of fatalism, resignation, world-weariness — that is as much a part of the Italian experience as breathing.

To Italians, gesturing comes naturally. Some even joke that gesturing may even begin before birth.

Isabella Poggi, a professor of psychology at Roma Tre University and an expert on gestures, has identified around 250 gestures that Italians use in everyday conversation.

References:

When Italians Chat, Hands and Fingers Do the Talking - NYTimes.com, 2013 http://nyti.ms/18x8ntc

Worst disaster in the history of Mount Everest climbs and the only doctor on the mountain

TED Med: Ken Kamler: Medical miracle on Everest.

When the worst disaster in the history of Mount Everest climbs occurred, Ken Kamler was the only doctor on the mountain. At TEDMED, he shares the incredible story of the climbers' battle against extreme conditions and uses brain imaging technology to map the medical miracle of one man who survived roughly 36 hours buried in the snow.

Worldwide number of new TB cases is higher than any other time in history

From the 2011 Lancet review:

The worldwide number of new TB cases is more than 9 million - higher than at any other time in history.

22 low-income and middle-income countries account for more than 80% of the active cases in the world.

Due to the devastating effect of HIV on susceptibility to TB, sub-Saharan Africa has been disproportionately affected and accounts for 4 of every 5 cases of HIV-associated tuberculosis.

Management problems include:

- In highly endemic areas, TB diagnosis continues to rely on century-old sputum microscopy

- No vaccine with adequate effectiveness (although BCG works to some extent). According to a recent report, BCG vaccination not only protects against tuberculosis but the number needed to treat (NNT) is 11.

- TB treatment regimens are protracted and have a risk of toxic effects

- Increasing rates of drug-resistant tuberculosis in eastern Europe, Asia, and sub-Saharan Africa

Promising progress includes improved tuberculosis diagnostics with biomarkers of disease activity. New and improved drugs, biomarkers, and vaccines need to be developed.

Diagnosing tuberculosis with cytokines IL-15, IL-10 and MCP-1, in addition to interferon-gamma

A pattern of two cytokines, called MCP-1 and IL-15, was reasonably good at differentiating between persons sick with TB and persons infected but not sick.

Monocyte chemotactic protein-1 (MCP-1) is a small cytokine belonging to the CC chemokine family. According to the new nomenclature, MCP-1 is called chemokine (C-C motif) ligand 2 (CCL2).

A third cytokine called IP-10 also showed promise at differentiating between people who are infected and those who are not.

Interferon gamma-induced protein 10 kDa (IP-10) is also known as C-X-C motif chemokine 10 (CXCL10). It belongs to the CXC chemokine family.

These 3 cytokines could form the basis of a new test to quickly detect whether tuberculosis is dormant or active and infectious.

52 chemokines from 4 families have been described. They interact with 20 receptors (click here for a larger image).

References:

Tuberculosis. Stephen D Lawn MRCP, Prof Alimuddin I Zumla FRCP. The Lancet, Volume 378, Issue 9785, Pages 57 - 72, 2 July 2011.

Immune system could be used to test for TB. Reuters.

Immunology Made Simple: "What are These People Talking About?"

Cytokines

Xpert MTB/RIF is a rapid diagnostic test for tuberculosis with high sensitivity (90%) and specificity (99%). Lancet, 2011.

Image source: PPD, CDC, public domain.

Comments from Twitter:

@sdietrich17: How discouraging. We just keep going backwards with so many infectious diseases...

Hepatitis c: teenage jazzy history

NHS Choices: Teen jazzy with hepatitis c. This born is your life daily video with the disease.

Comments from Twitter:

@napernurse: Life in the United Kingdom, where comprehensive like med/psychology recipes for global NHS covered. As a liver transplant that also handled.